Known Issues with VMware vSphere 7.0, particularly in relation to Citrix products:

1. Citrix Virtual Apps and Desktops MCS Provisioning

• Issue: There are concerns regarding the support for Citrix Virtual Apps and Desktops MCS provisioning with VMware vSphere 7.0.
• Symptoms: Users may experience delays or failures in provisioning virtual machines.
• Solution: VMware vSphere 7.0 is targeted for support in Q3, and fixes will be ported back to the 1912 LTSR upcoming CU releases 

2. Error Creating or Updating Catalogs

• Issue: When updating or creating a new catalog after upgrading to vSphere 7.0 CU1 and later, users may see errors in Studio or PowerShell.
• Symptoms: Errors such as "FailedToCreateImagePreparationVm" and "A specified parameter was not correct: deviceChange[1].device.key."
• Solution: Upgrading to the following versions should resolve the problem:
• Virtual Apps & Desktops - 7.15 CU7 and later
• Virtual Apps & Desktops - 1912 LTSR CU2 and later
• Virtual Apps & Desktops - 2009 and later

3. LTSR Support for vCenter 7.0

• Issue: Users are inquiring about when Citrix Virtual Apps and Desktop LTSR will support vCenter 7.0 as a hypervisor.
• Solution: vSphere 7.0 and 7.0 U1 is supported with CVAD 1912 CU2 and will be supported with 7.15 CU7, targeted for the first half of Q1 2021 

4. Connection Issues with vSphere

• Issue: Users may experience issues connecting to vSphere 7.0, particularly with permissions or configuration settings.
• Symptoms: Errors related to permissions or inability to establish a connection.
• Solution: Ensure that the required vSphere permissions are set correctly. Refer to the Citrix documentation for defining VMware vSphere user privileges

5. General Compatibility Issues

• Issue: VMware vSphere 7.0 may not be compatible with older versions of Citrix products, leading to various operational issues.
• Recommendation: Always ensure that you are using the latest compatible versions of Citrix products with VMware vSphere to avoid compatibility issues 

Summary of Recommendations

• Update Drivers: Ensure that all drivers, especially for graphics cards, are updated to the latest versions compatible with vSphere 7.
• Test Deployments: Conduct thorough testing in a lab environment before rolling out updates to production systems.
• Monitor Citrix Support Articles: Regularly check Citrix support articles for updates on known issues and their resolutions.

https://support.citrix.com/s/article/CTX131239-supported-hypervisors-for-citrix-virtual-apps-and-desktops-mcs-and-citrix-provisioning-pvs?language=en_US