When users opened launched IE11 brower, an warning message may occur as below:
Citrix HDXJsInjectr from Citrix Systems,inc is incompatible with Internet Explorer's Enhanced Security Features

Caution! Using Registry Editor incorrectly can cause serious problems that might require you to reinstall your operating system. Citrix cannot guarantee that problems resulting from the incorrect use of Registry Editor can be solved. Use Registry Editor at your own risk. Be sure to back up the registry before you edit it.

Delete the following four registry values on Server VDA side:
HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Windows\CurrentVersion\Policies\Ext\CLSID
HKEY_LOCAL_MACHINE\SOFTWARE\WOW6432Node\Classes\CLSID\{CA076BDE-8E41-44EE-B775-E791F26D0483}
HKEY_LOCAL_MACHINE\SOFTWARE\WOW6432Node\Microsoft\Windows\CurrentVersion\Explorer\Browser Helper Objects\{CA076BDE-8E41-44EE-B775-E791F26D0483}
HKEY_LOCAL_MACHINE\SOFTWARE\WOW6432Node\Microsoft\Windows\CurrentVersion\Policies\Ext\CLSID

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Problem Cause

Citrix HDXJsInjector plugin is incompatible with Internet Explorer enhanced protected mode like many third party plugins.