Citrix Workspace App and Citrix Receiver cannot launch applications automatically with Safari version 12.
SERVER SIDE CHANGES
For StoreFront deployments, modify web.config under the Receiver for Web (RfWeb) site (typically C:\inetpub\wwwroot\Citrix\StoreWeb) to activate the Citrix Receiver Launcher / Citrix Workspace App Launcher for Safari 12 and later.
1. Open web.config using your preferred text editor and locate the line : <protocolHandler enabled="true" platforms="(Macintosh|Windows NT).*((Firefox/((5[2-9]|[6789][0-9])|\d\d\d))|(Chrome/((4[2-9]|[56789][0-9])|\d\d\d)))" skipDoubleHopCheckWhenDisabled="false" />
2. The value of the platforms attribute is a regular expression specifying the browsers that Citrix Receiver Launcher is used for client detection and HDX launches. Change the regular expression to:
"(Macintosh|Windows NT).*((Firefox/((5[2-9]|[6789][0-9])|\d\d\d))|(Chrome/((4[2-9]|[56789][0-9])|\d\d\d)))|Macintosh.*Version/(1[2-9]|[2-9][0-9]).*Safari/"
3. This will add Safari 12 and later to the list of browsers that Citrix Receiver Launcher will be used.
CLIENT SIDE CHANGES
On a Mac Station running Safari 12 perform the following actions:
Apple removed support for NPAPI in Safari 12.
You can now use the Application probing feature to proactively monitor the health of applications enabling you to fix issues before the user actually experiences them. For more information refer to Citrix Documentation - Application probing.
Citrix Blogs - NPAPI support is being removed from Safari 12