On a server with the 7.15 LTSR CU1 VDA installed, winlogon spams the HKLM\Software\Citrix\Ica\Session(SessionNumber)\InitialProgram key with queries in the over of millions of times on a server with ~30 sessions resulting in higher CPU usage.
The issue is fixed under LC9450 and the public fix for this issue is released in 7.15 LTSR CU3.
https://docs.citrix.com/en-us/xenapp-and-xendesktop/7-15-ltsr/whats-new/cumulative-update-3/fixed-issues.html
Twi3.dll querying initialProgram quite frequent. The query is time consuming and impacts the server performance.