Citrix ADC appliance supports one-time passwords (OTPs) without having to use a third-party server. One-time password is a highly secure option for authenticating to secure servers as the number or passcode generated is random. Previously, OTPs are offered by specialized firms, such as RSA with specific devices that generate random numbers. This system must be in constant communication with client to generate a number expected by the server.
To know the Native OTP workflow, prerequisites, configuration using GUI/ CLI, registration and login to Citrix ADC, refer to https://docs.netscaler.com/en-us/citrix-adc/current-release/aaa-tm/authentication-methods/native-otp-authentication.html