It was observed that when Netscaler initiates the connection to back end ,Back end server is closing the SSL handshake with an error Fatal description handshake failure. Netscaler is resetting the connection with reset code 9818.Looking at the trace it can be inferred that the minimum supported SSL version for the back end server was TLS version 1.2.The maximum support version on Netscaler for the back end service is TLS 1.0 and due to this the SSL handshake is failing.

1)Upgrade to 11.0 65 .This has support for TLS version 1.1 and 1.2 for back end connections.
2)Create an SSL bridge. 
3)Allow minimum supported version of TLS version 1.0 for the back end server. 

Problem Cause

Unsupported SSL version on the back end server.