Microsoft SharePoint when accessed through NetScaler AAA and load balanced virtual server has certain options disabled (editing).
Direct access to SharePoint server has no issue.
To resolve this issue reduce the HTTP Response body size and then clear the browser cookie/cache.
The disabled SharePoint options will now be accessible.
A misconfigured rewrite expression caused NetScaler to take longer time to process the request and eventually not perform the action.
In this case the rewrite response body had HTTP.RES.BODY(2000000000) as target to choose. This large body check will take longer and might fail in some cases.