When a user logs off the VDI desktop then logs back in, opening any Office 365 app prompts for two-factor authentication login. This was not happening before the upgrade.

Upgrade to 2202. We no longer scrub the directory, %localappdata%\Packages\Microsoft.AAD.BrokerPlugin_cw5n1h2txyewy,  unless explicitly told to via a setting.

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Problem Cause

The issue was being caused by us following the recommendations of this article: https://docs.microsoft.com/en-us/azure/active-directory/devices/howto-device-identity-virtual-desktop-infrastructure from MS, and scrubbing the directory.

MFA data not being saved for O365