After installing the Citrix HotfixProfilemgtWX64_1912_3001, an error is generated when opening Outlook:

OUTLOOK.EXE : Bad Image C:\Program Files\Citrix\User Profile Manager\upmoutlookhook64.dll is either not designed to run on Windows or it contains an error. Try installing the program again using the original installation media or contact your system administrator or the software vendor for support. Error status 0xc0000428.

As a workaround, replace the UpmOutlookHook.dll, UpmOutlookHook64.dll and UpmSearchSvcHook.dll binaries with ones from a non-patched VDA.
This known issue can be fixed by the hotfix ProfilemgtWX64_1912_3002 - Refer to  CTX322392