When running SQL Management Studio through TCP Vserver it connects fine, but though SSL_TCP you receive a connection error.
Error:
A connection was successfully established with the server, but then an error occurred during the pre-login handshake.
Error: 64

Problem Cause

Management Studio uses TDS (Tabular Data Stream) when connecting regardless of whether or not you tell it to encrypt data.  TDS always sends a pre-login packet to setup it's connection.  Netscaler is sending reset when it receives a TDS pre-login packet. This behavior is expected as the pre-login message is not SSL/TLS. Netscaler needs a client hello message to begin the TLS process.  Management Studio will use the pre-login process to setup TLS but the TLS will be within the TDS and not directly inside TCP.