During VDA installation error Installation of MSI File 'IcaTS_x64.msi' failed with code 'InstallFailure' (1603). XenDesktopSetup:Citrix HDX TS failed to install, with internal error code 65535, failing action was "CA_HwDev_icak2m", on operation "MSIEntry". XenDesktopSetup:InstallComponent: Failed to install component 'ICA for Remote Desktop Services'. Installation of MSI File 'IcaTS_x64.msi' failed with code 'InstallFailure' (1603).

Citrix is not responsible for and does not endorse or accept any responsibility for the contents or your use of these third party Web sites. Citrix is providing these links to you only as a convenience, and the inclusion of any link does not imply endorsement by Citrix of the linked Web site. It is your responsibility to take precautions to ensure that whatever Web site you use is free of viruses or other harmful items.

Restore Windows folder permissions to match a working system. 
Directory C:\Windows
Administrator and System - Full Control Folder and subfolders
nt service\trustedinstaller - Read & Execute

---

Problem Cause

Invalid system folder permissions