Gateway: "The connection to "Desktop/App Name" failed with status (Unknown client error 1110)"
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Article ID: CTX284944
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Updated On:
Description
Error while launching " The connection to "Desktop/App Name" failed with status (Unknown client error 1110)"

Resolution
Possible solution 1:
DTLS traffic MTU is lower or greater than 1500. This is a specific issue known by Citrix support who actively works to resolve this issue. The fix is available on release 11.1 55.x and 12.0 53.x. (BUG686774)
Possible Solution 2:
Citrix ADC/Gateway on ESX/VMWare is using VMXNET3 and running a version of 12.1 lower than 12.1.58.20 :
From release notes of 12.1.58.20:
UDP applications (for example, DNS, TFTP, Radius, DTLS) might not work in Citrix VPX instances running on a VMware ESX server with VMXNET3 network interfaces.
[# 711445, 713549, 715567, 716984, 718232]
Problem Cause
MTU
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