Citrix ADC 12.1.48.x can share the AD attribute used by a third party software. Even if that is not recommended at all.
Citrix ADC 12.1.50.x and later versions require an AD attribute to be used exclusively for Native OTP configurations.If NS ADC detects data in the attribute that is not the format expected, then, the process, from the NS point of view will fail, not data modification will be done in the AD attribute field.
As a general rule:
The AD attribute must be exclusive for native OTP configurations.