In high latency networks such as Vsat 128kbps link, launching of a published desktop or published application may fail with the error "Connection Interrupted" when Adaptive Transport Policy is enabled.
The connection error happens due to network fragmentation with NetScaler Gateway versions 11.1.54.x or older.
Also, performance or connection issues could happen if the underlying network alters the MTU to any value below 1500.
Reducing the EDT MSS to a smaller value would resolve the problem. Default value for EDT MSS is 1500. You can modify the default EDT MSS value by editing the Default ICA file for the corresponding store on the Storefront server.
Please refer to the below article:
How to Configure MTU when using EDT across VPN solutions
https://support.citrix.com/article/CTX231821.