This article provides guidelines for configuring antivirus software in environments using Citrix Profile Management Technology . These antivirus guidelines are not vendor-specific and are independent of the version of Citrix Profile Management deployed, except where explicitly stated.

For Citrix Profile Management , Add directory exclusion in the antivirus for the path : C:\Program Files\Citrix\User Profile Manager . If antivirus doesn't support directory exclusion , add all the files in this location to files exclusion in antivirus software.
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In addition to this , if the local profiles are retained , include the path "C:\Users " , under directory exclusion as well on the antivirus software

Additional Resource

• CTX127030 - Citrix Guidelines for Antivirus Software Configuration
• CTX124185 - Provisioning Services Antivirus Best Practices
• CTX220622 - Citrix Guidelines for Antivirus Software Configuration for Citrix Profile Management
• Citrix Blogs - Citrix Recommended Antivirus Exclusions