1) Create new policy from AppCenter
2) New policy will not get applied to user/computer 
3) Clear GPO cache from C:\Programdata\Citrix\GroupPolicy
4) Execute GPUPDATE /FORCE. Policy node of Citrix will not get updated

Complete the following steps:

1. Install hotfixes from following articles: https://support.citrix.com/article/CTX202233 and https://support.citrix.com/article/CTX222714 on XenApp servers.
2. Stop IMA & Group Policy Engine service on XenApp servers.
3. Delete GPO cache from C:\Programdata\Citrix\GroupPolicy folder.
4. Recreate LHC using "dsmaint recreatelhc" command on the XenApp server.
5. Start IMA & Group Policy Engine services.
6. Run gpupdate /force command.

Problem Cause

XenApp servers are unable to retrieve fresh policy details from database.