Below troubleshooting steps were taken to further troubleshoot and fix the issue:
In the NetScaler trace file we could see that the GET request for the root page is being received from client and NetScaler sent it back to the backend server as well. Then backend server starts sending the data which NetScaler starts Ack’ing but in the end we see NetScaler resetting the frontend and backend connection as shown below with RST code 9205 (Follow the frontend and backend stream in WireShark) :

At the same time we see NetScaler is incrementing following http counters:
75 7001 1527735 8 1 http_err_noreuse_link_server Thu Nov 19 08:27:25 2015
76 7002 1527743 8 1 http_err_noreuse_link_server Thu Nov 19 08:27:32 2015
77 0 34905 2 0 http_err_noreuse_morethanCtLen Thu Nov 19 08:27:32 2015
78 7001 1527748 5 0 http_err_noreuse_link_server Thu Nov 19 08:27:39 2015
79 0 34907 2 0 http_err_noreuse_morethanCtLen Thu Nov 19 08:27:39 2015
Counter Information: http_err_noreuse_morethanCtLen
Number of connections that are not reused because Netscaler received more than content-length amount of data from server.- From nstrace we see that when backend sends NETSCALER 200 OK for the GET request the Content Length is as below highlighted:
GET / HTTP/1.1
Host:
www.XXX-domain.com
Connection: keep-alive
Accept: text/html,application/xhtml+xml,application/xml;q=0.9,image/webp,*/*;q=0.8
Upgrade-Insecure-Requests: 1
User-Agent: Mozilla/5.0 (Windows NT 6.1; WOW64) AppleWebKit/537.36 (KHTML, like Gecko) Chrome/46.0.2490.86 Safari/537.36
Accept-Encoding: gzip, deflate, sdch
Accept-Language: de-DE,de;q=0.8,en-US;q=0.6,en;q=0.4
HTTP/1.1 200 OK
Date: Thu, 19 Nov 2015 08:27:27 GMT
Server: Apache/2.4.10 (Linux/SUSE)
Set-Cookie: fe_typo_user=f5b877eabc219343b8412f88b3389b89; path=/; httponly
Set-Cookie: PHPSESSID=2r1iv4qf27c3vrqs48ujemn4u6grbavr9v9na7joune97sju2l41; path=/; HttpOnly
Expires: Thu, 19 Nov 1981 08:52:00 GMT
Cache-Control: no-store, no-cache, must-revalidate, post-check=0, pre-check=0
Pragma: no-cache
Content-Length: 38753X-UA-Compatible: IE=Edge,chrome=1
Keep-Alive: timeout=15, max=100
Connection: Keep-Alive
Content-Type: text/html; charset=utf-8
From the NetScaler nstrace we can see that the problem is with the server sending more than “Content-Length” bytes (There is 2 bytes of more data sent by backend as compared to what is specified in Content-Length header) in the all the responses where the RST is being triggered by NetScaler (Below is the TCP header of the last 200 OK response received from backend):
Recommendation that fixed the issue
Create a new HTTP profile (Under System > Profiles > HTTP Profiles) with following option enabled “Drop extra data from server” and bind it to the service and that should fix the issue. It can be globally applied by modifying the default HTTP profile.

Problem Cause
The HTTP response is sent by the backed server to the NetScaler, but NetScaler did not transfer any data to the browser and users see the error "Page cannot be displayed". Other pages (for example http://test.com/test1) on the same webserver are accessible without any problem. Accessing the root page directly (without NetScaler) works as well.
The problem is with the backend server sending more than “Content-Length” bytes (There is 2 bytes of more data sent by backend as compared to what is specified in Content-Length header) in the response in all cases where the RST is being sent by NS.