The Client and EPA Plug-ins don't work with the latest Chrome versions as support for NPAPI is disabled by default. The support will be deprecated entirely in Chrome version 45 in September 2015.

From Chrome version 42, all NPAPI plugins will appear as if they are not installed. This will affect customers upgrading from 10.5 to 11.0. This is also applicable to customers who upgrade from 11.0 Beta builds and later Release builds. Affected customers will see a download prompt even though the VPN or EPA plugin is installed.

To resolve this issue, upgrade to NetScaler 11.0 63.16 which has the fix for this issue.

More about NPAPI deprecation can be found here: http://support.google.com/chrome/answer/6213033?hl=en