During an application launch, a Windows splash screen stating "Applying computer settings, Loading User profile...." is displayed, instead of a progress bar.

Update the following registry key on the XenApp server(s) to resolve the issue:
Caution! This fix requires you to edit the registry. Using Registry Editor incorrectly can cause serious problems that might require you to reinstall your operating system. Citrix cannot guarantee that problems resulting from the incorrect use of Registry Editor can be solved. Use Registry Editor at your own risk. Be sure to back up the registry before you edit it.
Registry Key: HKEY_LOCAL_MACHINE\SOFTWARE\Wow6432Node\Citrix\Logon
Name: DisableStatus
Type: REG_DWORD
Value: 00000000

Problem Cause

The exact cause for this issue is not known; however, it could be an architectural change in Windows 2008 R2.

CTX135782 - Black Screen Connecting to  Published Desktop
CTX129229 - Recommended Hotfixes for XenApp 6.0 and later on Windows Server 2008 R2