Single-label DNS names are DNS names that do not contain a suffix such as .com, .corp, .net, or .org. For example, contoso would be an SLD while contoso.com, contoso.net, or contoso.local would not be an SLD.
Although SLD is not a common configuration worldwide, some Microsoft products can be installed in an SLD and other uncommon namespace configurations; certain considerations might apply as noted by individual product groups. Existing products might continue to function with SLDs, but SLDs are not a recommended configuration for future deployments, and might not work with some products or versions. Other Microsoft or third party applications that end-users might wish to run in your environment might not be compatible on an SLD. Microsoft recommends that customers deploy infrastructure using common, tested configurations to minimize extra deployment and testing costs.
Citrix is not aware of any issues with SLDs.
SLDs are not a recommended configuration for Microsoft products and Citrix adopts the same recommendation.
Microsoft Support for Single Label Domains
Information about configuring Windows for domains with single-label DNS names
Administering Active Directory Domain Rename
Active Directory Installation Warnings in Domains with Single Label DNS Names